Sitting joint top level par with Chelsea, Benitez will be hoping to continue their title challenge a little longer than last season where a mid season collapse saw his side fall out of the run for the title.
The summer saw many new faces arrive and saw some faces leave. John Arne Riise was one of the big name players out of the door after a very successful spell at the Merseyside club.
On the incoming front, Big money signing Robbie Keane was the main talking point since his arrival from Tottenham in a £20m deal and he should lead the attack with Fernando Torres a major doubt after limping out of Spain's win over Belgium mid week.
After a busy week of internationals, Steve Bruce will be hoping to have a fully fit squad but this will more than likely not be the case.
Emile Heskey limped out of England's 3-1 win over Belarus, Amr Zaki missed Egypt's win against Djibouti so attack wise, Wigan could be light in that department.
After the disappointment of the Middlesbrough game, a trip to Anfield is a fixture Bruce would not have chosen to play in the next game but never the less, Anything is possible in football with Stoke claiming a point at Anfield earlier in the season.
Team News
Assuming all players return in a good state of manner from international duty, Bruce could make one or two changes to keep the squad fresh. Zaki is a big doubt after tearing his hamstring which will be a massive blow with Henri Camara returning to the starting XI if this happens.
Kirkland
Melchiot Scharner Bramble Figueroa
Valencia Cattermole Palacios Koumas
Heskey Camara
Key Players for Liverpool
Pepe Reina - Reina is a big player for Liverpool who is very consistant and is an accomplished penalty stopper
Jamie Carragher - A product of the youth academy, Carragher is solid in the Liverpool back four and performs key defensive duties. The vice captain is highly regarded by all at Liverpool
Steven Gerrard - A real match winner, can produce something out of nothing and a real grafter who fights for every ball. Will be hard to pin down
Robbie Keane - Without Torres, the main threat from attack comes from Keane who will be expected to test the Back four and Kirkland all game. An all round striker who can score magnificent goals or simple tap ins
Prediction
A very tough trip for Bruce and his men and Liverpool could have too much for Wigan. Melchiot and co. to give it a real go but Liverpool ending up eventual winners
WAFC 1 - 2 LFC