And by half-time shell-shocked Wigan were left wondering just what had hit them.
Bellamy, who was cleared of assault charges at Cardiff during the week, came in for the injured Peter Crouch and hammered the Reds into the lead after nine minutes.
John Arne Riise's long ball took a deflection off the head of Wigan defender Fitz Hall and Bellamy was too fast for veteran centre-back Matt Jackson before beating former Liverpool keeper Chris Kirkland with a terrific strike from just inside the box.
Incredibly that was only the second goal Liverpool had scored on their travels this season but it clearly lit the fuse as they found the cure for the away day blues.
Bellamy was just wide with a header before Wigan produced their first threat when Australian international Josip Skoko picked out the unmarked Paul Scharner and he provided the cross for Henri Camara, but he failed to come up with a finish to trouble Jose Reina.
Then disaster struck again in the Wigan defence. Xabi Alonso cashed in when Skoko failed to clear the ball inside the area and his ball again struck defender Hall's head.
Alonso instantly seized on it to play Bellamy in and he made no mistake placing the shot beyond Kirkland as the keeper raced out.
Wigan went close to pulling one back when Reina saved from point-blank range after Scharner powered in a header from six yards.
The Latics' luck was out again when Reina blocked a shot from Emile Heskey and Camara was wide with the follow-up.
Liverpool then struck again with a beautifully crafted goal. This time Bellamy turned provider to set up number three for Dirk Kuyt with Steven Gerrard also involved in the build up.
More agony followed for Wigan just before the break when Gerrard's ball into the box struck Lee McCulloch's leg and found it way into the net for the fourth.
Wigan made changes at half-time with David Cotterill coming on for Kevin Kilbane and David Wright replacing Jackson.
They did have the ball in the Liverpool net through Scharner but the Austrian was just offside as he headed home.
Liverpool were inches away from adding to the lead when skipper Gerrard blasted one just over the bar after Wigan were caught on the break with Bellamy's speed off the mark again causing major problems for the defence.
Lady Luck was against the Latics again when Camara had a shot blocked and Heskey hit the post with the follow up.
And with seven games to come in December - including clashes against Chelsea, Manchester United and Arsenal - it threatens to be a testing month for Paul Jewell's team after two defeats on the trot.