Four million pound man Phil Jagielka is set to start the game at full back. The former Sheffield United player was a target for the Latics over the summer before his move to Goodison.
James Beattie and Gary Naysmith both left the club over the summer leaving David Moyes with limited options.
For Wigan, it is expected that Kevin Kilbane will take Leighton Baines' birth at left back for the Latics with no replacement for the England under 21 international forthcoming.
Michael Brown is suspended whilst Ryan Taylor is not yet fit.
Julius Aghahowa should start up front alongside Emile Heskey with Antonio Valencia, Paul Scharner, Denny Landzaat and Jason Koumas across midfield.
Everton (from): Howard, Hibbert, Valente, Stubbs, Yobo, Lescott, De Silva, Carsley, Arteta, Osman, Johnson, Anichebe, Ruddy, Boyle, Pienaar, Neville, Van der Meyde, Jutiewicz.
Wigan (from): Kirkland, Melchiot, Boyce, Bramble, Hall, Kilbane, Valencia, Koumas, Skoko, Landzaat, Cotterill, Sibierski, Camara, Heskey, Aghahowa, Nash, Pollitt, Folan, Granqvist.
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